Cognition Therapeutics

Elayta Crossed Blood Brain Barrier and Reached CNS Levels Associated in Preclinical Studies with Cognitive Improvement

Pittsburgh, Feb. 19, 2019 (GLOBE NEWSWIRE) — Cognition Therapeutics, Inc., a clinical stage neuroscience company focused on the protection and restoration of synaptic function in neurodegenerative disorders, announced today the publication of clinical data from the Company’s Phase 1 trial of Elayta™ (CT1812) in Alzheimer’s & Dementia: Translational Research & Clinical Interventions.

Top-line findings from this two-part randomized, double-blind, placebo-controlled Phase 1 study had previously been reported as part of a “Late Breaker” Oral Presentation at the 9th Annual Clinical Trials on Alzheimer’s Disease (CTAD) meeting. Results showed that Elayta was well tolerated by the 93 study participants, with mild headache and GI disturbances representing the most commonly observed adverse events. At peak plasma concentrations, dose-dependent increases in cerebrospinal fluid (CSF) levels of Elayta were measured, confirming that Elayta crossed the blood-brain barrier. No differences in plasma levels of Elayta were detected between cohorts of patients who were fed versus those who had fasted.